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In Vivo Imaging Instruments

Whether you’re trying to understand biology pathways, monitor disease progression, or evaluate drug candidates earlier in drug development, our wide portfolio of preclinical imaging systems are designed to support your research needs.

Offering high-throughput capability and sensitivities to image down to a single cell our IVIS™ technology continues to pave the way in small animal optical imaging. With over 20 years experience in preclinical in vivo imaging, our industry leading IVIS optical imaging systems are the most published platform for bioluminescence and fluorescence imaging with over 27,000 peer-reviewed publications.

The Quantum™ GX3 can be used for a diverse array of research applications such as lung and cardiac imaging made possible through fast image-based gating techniques, in vivo and ex vivo bone imaging, and other soft tissue applications. This standalone microCT system features a highly sensitive, high resolution flat panel detector enabling fast scanning with high image signal-to-noise and low radiation exposure for repeated CT scans used in longitudinal imaging studies.

In addition to optical and microCT modalities, we also offer the first ultrasound system that combines automated, hand-free technology with high-throughput capability - the innovative Vega preclinical ultrasound system that can deliver 2D and 3D images in just a few minutes.


For research use only. Not for use in diagnostic procedures.

In Vivo Imaging Instruments

Vega preclinical ultrasound

  • Hands-free, automated transducer positioning and movement
  • High speed, high-throughput performance with 3 mice scanning in just a few minutes
  • 3D Widefield acquisitions enabling whole subject imaging
  • Standard B-mode and M-mode capability
  • Shear Wave Elastography (SWE) mode for quantifying and evaluation tissue stiffness
  • Acoustic angiography mode for visualizing microvasculature
  • Fits on the benchtop
Vega Preclinical Ultrasound System
Vega Preclinical Ultrasound System
Designed with the researcher in mind, the Vega removes the challenges associated with traditional hand-held ultrasound, and uses a bottom-up imaging approach through the use of automated hands-free transducers located under the imaging stage. This unique design requires minimal training with no dedicated sonographer needed, enables high-throughput imaging, and produces more consistent results than conventional hand-held ultrasound systems. This powerful ultrasound system gives you:
  • Hands-free - Automated transducer positioning and movement
  • Easy-to-use requiring minimal training
  • High-speed, high-throughput performance with 3 mice scanning in just a few minutes
  • 3D widefield acquisitions enabling whole subject imaging
  • Standard B-Mode and M-Mode capability
  • Shear Wave Elastography (SWE) mode for quantifying tissue stiffness
  • Acoustic Angiography (AA) mode for visualization of microvasculature
  • Flexible visualization and analysis software
  • Fits on the benchtop
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IVIS Lumina S5 & X5

  • High-sensitivity 2D optical imaging (bioluminescence and fluorescence)
  • High-throughput format with a 20 x 20 FOV sufficient for imaging 5 mice simultaneously
  • High resolution, low dose X-ray with optical overlay (IVIS Lumina X5 only)
  • Compact design that fits on your benchtop
  • Unique animal handling accessories and software tools to streamline throughput
  • Complimentary Living Image™ software licenses are provided with the IVIS systems and upon request. 
IVIS Lumina S5 2D optical imaging system
IVIS Lumina S5 Imaging System
The IVIS Lumina S5 in vivo imaging system has all the capabilities of the current IVIS Lumina platform with improved throughput and accessories to streamline imaging workflow, data acquisition and analysis, ideal for accelerating your research. High-throughput High-Sensitivity Optical Imaging The IVIS Lumina S5 integrates a next generation 1 inch CCD camera into our benchtop instrument providing a high throughput 20 x 20 cm Field of View (FOV) sufficient for imaging 5 animals at a time for bioluminescence and fluorescence in vivo imaging. As with other IVIS Lumina in vivo optical imaging systems, the IVIS Lumina S5 is equipped with 26 filters tunable to image fluorescent sources that emit from green to near-infrared. Novel illumination technology effectively increases fluorescent transmission through 900 nm. Moreover, the IVIS Lumina S5 incorporate Revvity's patented Compute Pure Spectrum (CPS) algorithm for spectral library generation software tools to ensure accurate autofluorescence removal, unmixing and fluorophore quantitation. Standard on all IVIS instruments, absolute calibration affords consistent and reproducible results independent of magnification, filter selection from one instrument to any another IVIS instrument within an organization or around the world. IVIS Lumina S5 – A High Throughput Solution Not only does the IVIS Lumina S5 offer higher throughput via the 1 inch CCD, but it is also compatible with a set of smart animal handling accessories (purchased separately) designed with throughput and safety in mind. Smart loading trays allows users to pose animals on the benchtop before placing the tray into the IVIS. Fiducials built into the tray enable the software to automatically recognize and draw ROIs providing automated animal identification. Animal trays are designed with ease of use and user safety in mind. No nose cones are required thus minimizing cleanup. When used with the next generation anesthesia unit (RAS-4), strong vacuum capabilities minimize excess gas from escaping thus preventing exposure of users to anesthetic gas. Finally, Living Image™ software brings IVIS technology to life by facilitating an intuitive workflow for in vivo optical image acquisition, analysis and data organization. The software’s design creates an intuitive, seamless workflow for researchers of all skill levels.  Key Features:
  • High throughput (5 mice) optical imaging
  • Increased throughput (10 mice) using optical manifold
  • Supports mouse and rat imaging
  • Compute Pure Spectrum (CPS) spectral unmixing
  • Full fluorescence tunability through the NIR spectrum
  • Unique accessories to speed acquisition and analysis
  • Small footprint–sits on your benchtop
  • Complimentary Living Image software licenses are provided with the IVIS systems and upon request.
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IVIS Lumina X5 2D optical imaging system
IVIS Lumina X5 Imaging System
The IVIS Lumina X5 has all the capabilities of the IVIS Lumina S5 imaging system with integrated industry leading high-resolution x-ray for greater detail. The IVIS Lumina X5 also includes state of the art spectral unmixing features for sensitive multispectral imaging to monitor multiple biological events in the same animal. High-throughput Optical and X-ray Imaging – No Compromise The IVIS Lumina X5 integrates a next generation 1 inch CCD camera into our benchtop instrument providing a high throughput 20 x 20 cm FOV sufficient for imaging 5 mice at a time with bioluminescence and fluorescence. Moreover, the large, independently deployed scintillator facilitates X-ray acquisitions of 5 mice and larger rodents up to 500-600 grams with seamless, accurate overlay onto the optical image at any field of view. As with other IVIS Lumina systems, this instrument is equipped with 26 filters tunable to image fluorescent sources that emit from green to near-infrared. Novel illumination technology effectively increases fluorescent transmission through 900 nm. Additionally, the IVIS Lumina X5 incorporates Revvity's patented Compute Pure Spectrum (CPS) algorithm for spectral library generation software tools to ensure accurate autofluorescence removal, unmixing and fluorophore quantitation. Standard on all IVIS instruments, absolute calibration affords consistent and reproducible results independent of magnification, filter selection from one instrument to any another IVIS instrument within an organization or around the world. Industry Leading X-ray Resolution The IVIS Lumina X5 is equipped with a microfocus X-ray source and geometric magnification and when combined, achieve industry leading X-ray resolution in a 2D optical/X-ray system setting a high standard in multimodal 2D imaging resolution. With optical image overlays at every X-ray resolution, never miss underlying anatomical and structural changes. Get more from your data and explore new applications. IVIS Lumina X5 – A High Throughput Solution Not only does the IVIS Lumina X5 offer higher throughput via the next generation 1 inch CCD, but it is also compatible with a set of smart animal handling accessories (purchased separately) designed with throughput and safety in mind. Smart loading trays enable users to pose animals on the benchtop before placing the tray into the IVIS. Fiducials built into the tray allows the software to automatically recognize and draw ROIs providing automated animal identification. Animal trays are designed with ease of use and user safety in mind. No nose cones are required thus minimizing cleanup. When used with the next generation anesthesia unit (RAS-4), strong vacuum capabilities minimize excess gas from escaping thus preventing exposure of users to anesthetic gas. Finally, Living Image™ software brings IVIS technology to life by facilitating an intuitive workflow for in vivo optical, X-ray image acquisition, analysis and data organization. The software’s design creates an intuitive, seamless workflow for researchers of all skill levels. Key Features:
  • High throughput (5 mice) optical and X-ray
  • Increased throughput (10 mice) using optional manifold
  • High resolution, low dose X-ray with optical overlay
  • Supports mouse and rat imaging
  • Compute Pure Spectrum (CPS) spectral unmixing
  • Full fluorescence tunability through the NIR spectrum
  • Unique accessories to streamline workflow, data acquisition and analysis
  • Complimentary Living Image software licenses are provided with the IVIS systems and upon request
Learn more

IVIS Lumina III series

  • 2D optical imaging (bioluminescence and fluorescence)
  • Low-dose X-ray with optical overlay (IVIS Lumina XRMS only)
  • Images up to 3 mice simultaneously
  • Compact design that fits on your benchtop
  • Complimentary Living Image™ software licenses are provided with the IVIS systems and upon request. 
IVIS Lumina Series III optical imaging system
IVIS Lumina LT In Vivo Imaging System
The standard instrument is equipped with full bioluminscence, radioisoptic (Cerenkov) imaging capabilities for 2D imaging and standard fluorescence. For more sophisticated fluorescent models, the Lumina LT can be upgraded to a full Lumina Series III. Features/Benefits:
  • Bioluminescence
  • Fluorescence
  • Radioisotopic Cerenkov Imaging
  • Compute Pure Spectrum Spectral Unmixing
  • DyCE Imaging (Optional Upgrade)
  • Extended NIR Range 150W Tungsten EKE
  • Absolute Calibration to NIST® Standards
  • Complimentary Living Image™ software licenses are provided with the IVIS systems and upon request. 
Learn more
IVIS Lumina Series III optical imaging system
IVIS Lumina III In Vivo Imaging System
The IVIS Lumina III is capable of imaging both fluorescent and bioluminescent reporters. The system is equipped with up to 26 filter sets that can be used to image reporters that emit from green to near-infrared. Superior spectral unmixing can be achieved by Lumina III’s optional high resolution short cut off filters. Features and Benefits
  • Market trusted technology offering the fullest suite of leading imaging technologies, reagents and support
  • Exquisite sensitivity in bioluminescence
  • Full fluorescence tunability through the NIR spectrum
  • Compute Pure Spectrum spectral umixing for ultimate fluorescence sensitivity
  • Expandable system tailored to your workflow
  • Complimentary Living Image™ software licenses are provided with the IVIS systems and upon request.
Learn more
IVIS Lumina XRMS optical imaging system
IVIS Lumina XRMS In Vivo Imaging System
The Lumina XRMS includes state of the art spectral unmixing for sensitive multispectral imaging to monitor multiple biological events in the same animal. Use our Living Image® software to automate all the controls and settings required for seamless image acquisition and processing. Typical X-ray image acquisitions take only 10 seconds and can be overlaid with both optical and photographic images. Superior Optical Imaging with Spectral Unmixing The IVIS Lumina XRMS Series III is capable of imaging all common fluorescent and bioluminescent reporters or dyes. The system is equipped with up to 21 filter sets to image reporters that emit from green to near-infrared. High resolution, sharp cut-off filters are simply interchangeable to achieve the highest performance, sensitivity and spectral unmixing. The Lumina XRMS imaging system also accommodates Petri dishes or micro-titer plates for in vitro imaging. The system can incorporate premium animal handling features such as a heated stage, gas anesthesia connections and a syringe injection system for simultaneous compound administration. Living Image software yields high-quality, reproducible, quantitative results incorporating instrument calibration, background subtraction and the image algorithms. Simple user guided spectral unmixing allows detection and separation of multiple reporters, and Living Image provides the precise overlay to see your optical reporters together with anatomical surface or X-ray features. Features and Benefits:
  • Multispecies optical and X-ray imaging
  • Image mice, rats and other large animals
  • High resolution, low dose digital X-Ray
  • Exquisite sensitivity in bioluminescence
  • Compute Pure Spectrum (CPS) spectral unmixing for ultimate fluorescence sensitivity
  • Full fluorescence tunability through the NIR Spectrum
  • Complimentary Living Image™ software licenses are provided with the IVIS systems and upon request.
Learn more

IVIS Spectrum 2 series

  • High sensitivity 2D and 3D bioluminescence & fluorescence imaging
  • High throughput simultaneous imaging of up to 10 mice
  • Fast data acquisition for rapid visualization of images in real-time
  • Two powerful modes of fluorescence excitation - epi-fluorescence and trans-illumination
  • Proprietary spectral unmixing algorithms for autofluorescence removal and multiplex imaging
  • Easy, one-click co-registration with the Quantum GX3 microCT system
  • Broadly adopted, easy to use, and intuitive, Living Image™ visualization and analysis software
  • Integrated low-dose, ultra-fast microCT (IVIS SpectrumCT 2 only)
  • Complimentary Living Image™ software licenses are provided with the IVIS systems and upon request. 
IVIS Spectrum 2 In Vivo Imaging System
IVIS Spectrum 2 In Vivo Imaging System
Building upon the IVIS Spectrum in vivo optical system with proven 2D bioluminescence and 2D fluorescence imaging and 3D optical tomography capabilities combined in a single system, the IVIS Spectrum 2 is our next generation in optical imaging. This advanced imaging system incorporates a CCD camera with eXcelon® coating that enables detection of more signal at higher efficiency across a broader spectrum of wavelengths. With exclusivity to this innovative camera for in vivo imaging, the IVIS Spectrum 2 preclinical optical imaging system delivers the sensitivity you demand for non-invasive longitudinal imaging to better understand early disease-related biological changes, track disease progression, and help guide the drug development process.
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IVIS SpectrumCT 2 In Vivo Imaging System
IVIS SpectrumCT 2 In Vivo Imaging System
The IVIS SpectrumCT 2 in vivo optical imaging system is an integrated platform that combines the full suite of IVIS optical features including; spectral unmixing and 2D and 3D quantitative bioluminescence & fluorescence imaging, with fast, low dose microCT imaging. Similar to the IVIS Spectrum 2 (part number CLS158738) optical imaging system, the IVIS SpectrumCT 2 incorporates a CCD camera with eXcelon® coating that enables detection of more signal at higher efficiency across a broader spectrum of wavelengths. The simple user interface along with advanced visualization and analysis tools are driven by our market leading, easy to use Living Image® software. The IVIS SpectrumCT 2 enables longitudinal workflows to characterize disease progression and therapeutic effect throughout the complete experimental time frame with both quantitative CT and optical reconstructions. Fast imaging and the ability to image multiple animals offers the throughput required to scan large cohorts of animals quickly and draw sound conclusions from your experimental data.
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Quantum GX3 microCT imaging system

  • Superior spatial resolution of 5 microns
  • Wide FOV range from 8 mm to 86 mm
  • Improved image-based respiratory gating
  • Proprietary active ring reduction
  • Continuous and step scanning modes
  • Seamless co-registration with the IVIS 3D optical imaging system
Quantum GX3 microCT imaging system
Quantum GX3 microCT System
The Quantum GX3 system represents the latest advances in microCT imaging with superior image resolution, high speed, low-dose, and flexibility. With the combination of higher resolution, increased field of view (FOV) range, and enhanced image-based respiratory and cardiac gating, the Quantum GX3 low-dose microCT system enables researchers to gain a better understanding of healthy and diseased tissue in a broad range of areas including bone, respiratory, cardiovascular, liver/kidney, brain, and oncology research.
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IVIS Spectrum 2 In Vivo Imaging System

This product replaces the IVIS™ Spectrum system (part number 124262). As the leader in optical imaging with thousands of publications using our flagship IVIS Spectrum platform, the IVIS Spectrum 2 system is the next generation in optical imaging. Designed with an innovative camera with patented coating that delivers high sensitivity 2D and 3D bioluminescence and fluorescence imaging capabilities - the IVIS Spectrum 2 gives you the flexibility you need for your in vivo imaging studies.

Part Number: CLS158738
IVIS SpectrumCT 2 In Vivo Imaging System

This product replaces the IVIS™ SpectrumCT system (part number 128201). For ultimate ease and flexibility, the IVIS SpectrumCT 2 in vivo optical imaging system integrates 2D & 3D bioluminescence and fluorescence imaging with low-dose CT combining both molecular functional and anatomical in vivo imaging into single system.

Part Number: CLS158737
IVIS Lumina S5 2D optical imaging system

The IVIS™ Lumina S5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence in a benchtop format. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data- and answers- on anatomical and molecular aspects of disease.

Part Number: CLS148588
IVIS Lumina Series III optical imaging system

The IVIS™ Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.

Part Number: CLS136331
IVIS Lumina X5 2D optical imaging system

High-Sensitivity Optical Meets High-Resolution X-rayThe IVIS™ Lumina X5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence with high-resolution x-ray into a compact system that fits on your benchtop. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data- and answers- on anatomical and molecular aspects of disease.

Part Number: CLS148590
Vega Preclinical Ultrasound System

The Vega™ ultrasound system is Revvity's latest addition of leading preclinical in vivo imaging technology. With an innovative design, Vega is a hands-free automated ultrasound platform that delivers high-resolution 2D and 3D imaging in just a few minutes.Hands-free, automated, high-throughput ultrasound

Part Number: D5240000
IVIS Lumina XRMS optical imaging system

Industry leading fluorescence, bioluminescence and x-ray imaging - All-In-One benchtop instrument! The IVIS™ Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with optical and x-ray overlay.

Part Number: CLS136340
IVIS Lumina Series III optical imaging system

The IVIS™ Lumina Series III brings together years of leading optical imaging technologies into one easy to use high sensitivity bench-top system.

Part Number: CLS136334
Quantum GX3 microCT imaging system

This product replaces the Quantum™ GX2 (part # CLS149276)The Quantum GX3 - advanced microCT system for ex vivo and in vivo imaging. The versatile Quantum GX3 microCT offers the flexibility researchers need by delivering the functionality to perform longitudinal studies, across a wide range of species, with fast, low-dose scanning and superior spatial resolution.

Part Number: CLS158459
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Technical Brief
Technical Brief
3D optical and microCT data – The power of multimodality imaging

3D optical and microCT data – The power of multimodality imaging

Literature - Publication Review
Literature - Publication Review
A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency

Surfactant Protein B (SP-B) deficiency is an uncommon, autosomal recessive lung disorder in term infants. This inability to produce SP-B leads to progressive, lethal, hypoxemic respiratory failure in the first year of life. The current standard of care is a lung transplant although rare due to availability of prenatal donor lungs. A compelling argument exists for gene therapy to treat this disease, as de novo protein synthesis of SP-B in alveolar type 2 epithelial cells is required for proper surfactant production. Learn how researchers designed an adeno-associated virus (AAV) 6 capsid that demonstrates efficiency in lung epithelial cell transduction in a mouse model using imaging with the IVIS ® SpectrumCT in vivo optical imaging system.

Scientific Poster
Scientific Poster
A novel image guided focused ultrasound platform for therapeutic delivery across the blood-brain barrier in mice

Case Study
Case Study
A novel mouse model using optical imaging to detect on-target, off-tumor CAR-T cell toxicity

CAR-T therapy has achieved tremendous success in treating blood malignancies, however treating solid tumors with this therapy has proven to be challenging due to several factors such as on-tumor, off-tumor toxicity. Read this case study where researchers from University of Pennsylvania created a mouse model that expresses tumor associated antigens in normal tissue to study off-tumor CAR-T cell toxicity. These studies used optical imaging on the IVIS ® platform to longitudinally monitor off-tumor antigen expression, tumor progression, and CAR-T cell trafficking in live animals.

Case Study
Case Study
A novel non-Invasive in vivo tool for the assessment of NASH

Non-alcoholic fatty liver disease (NAFLD) describes a progressive pathology that affects the liver. Fat accumulation causes fatty liver (NAFL) or steatosis to develop, which leads to lipotoxicity and in turn induces liver inflammation and apoptosis, resulting in non-alcoholic steatohepatitis (NASH). NASH can progress to fibrosis and then cirrhosis, which in some cases will lead to hepatocellular carcinoma (HCC). Read this case study to learn how non-invasive preclinical in vivo imaging was used to longitudinally visualize, quantify, and diagnose NASH with the goal of investigating the efficacy of liver fibrosis-preventing drugs on NAFLD progression.

Brochure
Brochure
A whole new perspective on ultrasound imaging

Introducing Vega ® - a novel ultrasound system that combines automated, hands-free technology with high-throughput capability for preclinical research. Hands-free - Automated transducer positioning and movement Easy to use - Requires minimal training Fast high-throughput imaging of 3 mice in just a few minutes 3D widefield acquisitions enabling whole subject imaging Multiple modes for multiple applications

Technical Note
Technical Note
Acquisition of high resolution images using IVIS optical imaging systems

Technical Note
Technical Note
Adaptive Fluorescence Background Subtraction for IVIS systems

Instrument background occurs when excitation light leaks through the emission filter. This occurs more frequently when the excitation and emission filters are narrowly separated. The ring you see is a result of non specific light reflecting off of the stage at an incident angle and passing through the filter causing what appears as leakage around the edges.

Scientific Poster
Scientific Poster
An AI approach for automated and noninvasive in vivo liver sizing in mouse models

Literature - Publication Review
Literature - Publication Review
Applications of In Vivo bioluminescence imaging for SARS-CoV-2

Scientists continue to explore several options to treat SARS-CoV-2 infection with hundreds of therapeutics at various phases of development. At the start of the pandemic, several factors hampered the rapid identification of potential SARS-CoV-2 therapeutics, including a limited understanding of the infection mechanism of the virus and the host immune response. Read this literature review to learn how scientists utilized non-invasive in vivo bioluminescence imaging to study SARS-CoV-2 progression and host immune response, as well as evaluating the efficacy of various antiviral strategies.

Case Study
Case Study
Assessing murine glioblastoma growth: a comparative study of ultrasound and MRI imaging modalities

Researchers at the University of North Carolina use automated, high throughput ultrasound and acoustic angiography as an alternative to MRI for tracking glioblastoma in mice. These results highlight the potential of ultrasound imaging using the Vega ™ for tracking tumor progression particularly in later stages when tumors are more easily detectable. Furthermore, these findings suggest that the Vega system could be used in drug discovery research to prioritize compounds for further evaluation before committing to MRI, which is more time-consuming and expensive.

Article
Article
Assessing nanomedicine delivery across the blood-brain barrier using pre-clinical in vivo imaging

We recently spoke to researchers based at the Centre for Advanced Imaging at the University of Queensland in Australia who have been utilizing various pre-clinical in vivo imaging techniques to explore the uptake of custom-designed nanomedicines at different stages of brain cancer. In this article, Professor Kris Thurecht, Dr. Zachary H. Houston, and Dr. Nick Fletcher discuss the rationale behind their approach and the personalized therapeutic potential of this methodology for patients with brain tumors in the future.

Application Note
Application Note
Assessment of arterial function using MicroCT imaging

Technical Note
Technical Note
AutoExposure

This tech note outlines procedures on using auto-exposure on the IVIS® preclinical optical imaging platform using Living Image® software.

Scientific Poster
Scientific Poster
Automated shear wave elastography captures MASLD onset in C57BL/6NTac mice preconditioned on a modified Amylin liver MASH diet

Case Study
Case Study
Automated ultrasound for non-invasive in vivo evaluation of liver disease progression in mice

Being able to characterize and monitor the extent of fibrosis, steatosis, and inflammation in the liver non-invasively is valuable to clinicians and researchers to comprehensively stage disease progression and evaluate therapeutic response. Read this review to learn how researchers used the Vega® automated, hands-free, high-throughput ultrasound system as a turnkey solution to evaluate, monitor, and quantify liver disease progression in murine models. Studies include: Evaluation of NAFLD using a mouse western diet mouse model Disease progression in a chemically induced mouse fibrosis model Monitoring treatment response in Mdr2 knockout mice Multimodal imaging of NAFLD/NASH progression in mouse model

Literature - Publication Review
Literature - Publication Review
Bacteria Eat Nanoprobes for Aggregation-enhanced Imaging and Therapy

This study uses a new imaging technique whereby bacteria consume a gold nanoprobe which aggregates intracellularly upon irradiation. Aggregation enhances signal intensity enabling visualization of unprecedented low quantities of bacteria. Multimodal in vivo fluorescence was used to locate bacterial colonies.

Brochure
Brochure
Biologics workflow solutions

Precision biologics are playing an increasingly powerful role as part of therapeutic strategies such as monoclonal antibodies, bispecific and multispecific antibodies, recombinant proteins, vaccines, and targeted next-generation cell and gene therapies. Harnessing large molecules to create safe and effective therapies is a complex and expensive undertaking. So we help scientists like you develop and streamline your entire biologics workflow, helping you overcome the challenges to bringing consistent, high quality, biological medicines to market – faster than ever before. Explore our solutions and technologies that cover areas of: Biomolecular discovery Biologics characterization Investigating immune function Manufacturing and QA/QC Safety and efficacy

Whitepaper
Whitepaper
Bioluminescence Resonance Energy Transfer (BRET) to monitor protein-protein interactions

The ability to image protein-protein interactions (PPIs) in vivo has important implications for a wide variety of biological research endeavors, including drug discovery and molecular medicine. The visual representation, characterization, quantification, and timing of these biological processes in living subjects can complement in vitro or cell culture methodologies. Read this white paper to learn how bioluminescence resonance energy transfer (BRET) was used to monitor PPIs using non-invasive in vivo imaging.

Technical Note
Technical Note
Bioluminescence tomography - setup and sequence acquisition

Technical Note
Technical Note
Bioluminescence tomography - source reconstruction and analysis

Technical Note
Technical Note
Bioluminescence tomography - topography

Literature - Publication Review
Literature - Publication Review
Biopolymers Codelivering Engineered T Cells and STING Agonists can Eliminate Heterogenous Tumors

Adoptive cell transfer using chimeric antigen receptor (CAR-T) cell therapy in which the patient’s T-cells are extracted, genetically modified, and transferred back into the patient with the aim that these altered cells can recognize and attack cancer cells has revolutionized cancer immunotherapy. Although very successful in treating hematological malignancies, CAR T therapy is more challenging in treating solid tumors. Learn how researchers at the Fred Hutchinson Cancer Research Center and University of Washington used the IVIS ® Spectrum non-invasive imaging system to evaluate the synergistic antitumor effect of co-delivery of CAR T cells and STING-agonists via biopolymer scaffolds in an orthotopic murine model of pancreatic cancer.

Technical Note
Technical Note
Brief overview guide on spectral unmixing

Application Note
Application Note
Cerenkov Imaging of Radioisotopes in IVIS systems

Optical imaging detects photons in the visible range of the electromagnetic spectrum. PET and SPECT imaging instruments are sensitive to photons in the much higher energy range of x-rays and gamma rays. While the PET and SPECT probes which can generate Cerenkov light in tissue will continue to produce the relevant gamma- and x-rays, visible photons will be produced from the Cerenkov emission, which the IVIS® will detect.