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Application Note
Rapid screening of novel therapeutics by ImmuSignature™ T cell activation assay
This application note describes the development of a robust T cell activation assay to assess the impact of novel therapeutics on T cell function.
Scientific Poster
Interchanging Cas enzymes, deaminases, and aptamerguide RNA combinations to achieve optimal editing with the modular Pin-point™ base editing platform
Learn how to apply multiplex base editing to efficiently develop engineered CAR-T cells and hypoimmunogenic iPSCs.
Application Note
Base editing with nuclease flexibility
In this application note, we demonstrate how the Pin-point™ base editing platform’s modularity allows for its components to be optimized to the target site.
Scientific Poster
Development and validation of customized guide RNA design and efficiency prediction tools for the Pin-point base editing platform
This scientific poster describes the development and validation of customized guide RNA design and efficiency prediction tools for the Pin-point base editing platform.
Application Note
Complex genome engineering with the Pin-point base editing system
This application note describes how Pin-point base editing platform can be applied to complex gene editing, even in sensitive cell types.
Whitepaper
Finding the right technology for your genome engineering project
Learn about how to select the right technology for your genome engineering project in this white paper.
Whitepaper
Generating a clonal HAP1LIG4(-) Cas9(+) cell line – an expert interview
An interview with Dr. Gerety, the Sanger Institute on generating a new HAP1 cell line and how it can help advance scientific discovery.
Application Note
Optimization of complement-dependent cytotoxicity assay on OncoSignature cell lines
This application note provides insight into how our complement-dependent cytotoxicity assay can help drug screening efforts by leveraging our semi-automated screening platform and OncoSignature™ cell panel.
Guide
Immune cell compound screening compendium
This application compedium provides an overview of four immune cell compound screening applications using ImmuSignature™ assays.
Whitepaper
CRISPR-derived base editing technology: The what, the how, and the why
This white paper provides a comprehensive guide to base editing, including what it is, how it works and applications.
Scientific Poster
One-step generation of allogeneic CAR-T cells by simultaneous multiplex knockout and site-specific transgene integration with the Pin-point™ base editing platform
Discover one-step generation of allogeneic CAR-T cells by simultaneous multiplex knockout and site-specific transgene integration with the Pin-point™ base editing platform.
Scientific Poster
Base Editing of Human Hematopoietic Stem and Progenitor Cells with the Base Editing of Human Hematopoietic Stem and Progenitor Cells with the Pin-point™ platform
Learn why the Pin-point™ base editing platform is a valuable tool for the generation of advanced cell therapies using sensitive cell types.
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