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Infographic
Disruptive innovation in protein degradation technologies
Discover this original infographic for in-depth insight about new protein degradation technologies including PROTAC, ATTEC, LYTAC, AUTAC.
Technical Note
Guidelines from PBMC isolation to cytokine assay optimization
This tech note will provide you with a complete step by step methodology to purify PBMCs and use them in cytokine quantification assays with HTRF
Infographic
The Story of Gene Therapy
This infographic gives you a short but clear insight into how gene therapies work.
Technical Note
Guidelines for optimizing protein-protein interaction assays using HTRF PPI reagents
This technical note reviews the general principles and steps in developing a protein-protein interaction assay using HTRF PPi reagents from Revvity assays.
Technical Note
Guideline for PBMC freezing
This technical note describes a protocol for freezing and thawing PBMC and provides details on functional validations after freezing the procedure compared to fresh PBMC.
Technical Note
The Inositol-Phosphate approach, a robust and stable platform for HTS of Gq coupled GPCR
This technical note presents data showing the stability and ease-of-use of the assay, optimal choice for robotic high throughput screening campaigns.
Technical Note
Optimize your HTRF cell signaling assays for tissues
This technical note gives precise guidelines for tissue lysate preparation, assay optimization, data analysis, and then interpretation, guaranteeing you will get accurate and interpretable results.
Technical Note
Optimization and pharmacological validation of wild type beta-arrestin 2 plasmid transfection
This technical note provides details on how transfecting cell lines with a beta-arrestin plasmid can lead to an increase in beta-arrestin 2 recruitment signals and restoration of beta-arrestin 2 in otherwise deficient cells.
Infographic
GPCRs and their prevalence in drug therapies
Discover a detailed GPCR infographic with biology background and approved drug therapies.
Infographic
Cell cycle infographic
Targeting various steps of the cell cycle is a promising strategy for cancer therapeutics. Learn more from our infographic.
Infographic
Protein recycling, TPD, and neurodegenerative disease
Targeted protein degradation (TPD) via the proteasomal and lysosomal pathways is a promising therapeutic approach that represents a novel tool for exploring cellular pathways. TPD offers several key advantages over traditional occupancy-based inhibitors, notably concerning dosing, drug resistance, and side effects.
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