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Expert interview: recapitulating the blood-brain barrier using in vitro hiPSC models in drug discovery
Better understand the blood-brain barrier for translational research and drug discovery in neurodegenerative diseases.

Biopolymers Codelivering Engineered T Cells and STING Agonists can Eliminate Heterogenous Tumors
Using the IVIS® Spectrum non-invasive preclinical optical system to quantify tumor-specific T cells responses in NFAT-luciferase transgenic mice.

DNA origami elevates the design of multispecific antibodies as cancer therapeutic agents
Publication review highlighting the use of the IVIS™ Lumina X5 optical imaging system and BioLegend Antibodies describe programmable T cell engagers (PTEs), a novel class of agents created with DNA origami, a nanotechnology that allows the precise spatial arrangement of biomolecules. When combined with antibodies, this approach holds great promise to develop specific and effective biomedical nanotherapies for diseases like cancer.

Morphological profiling of human T and NK lymphocytes by high-content imaging
The study in this publication review provides a foundation for the development of morphological profiling as a scalable approach to monitor the immune synapse (IS), primary lymphocyte responsiveness and microarchitecture.

Multifunctional mRNA-based CAR T-cells show promising anti-tumor activity against glioblastoma
Learn how researchers have evaluated the efficiency of mRNA-based multifunctional CAR T-cells against glioblastoma in vitro and in vivo.

Imaging and gene editing approaches highlight important role of autophagy in controlling Mtb infection
Learn how researchers used CRISPR-Cas9 gene editing and high-content imaging approaches to explore the role of autophagy in controlling Mtb infection.

hESC-derived cardiomyocyte screening platform identifies novel inhibitors of SARS-Cov-2 viral entry
Understand the pathology of SARS-CoV-2 in cardiomyocytes with a screening platform using human embryonic stem cell dervied cardiomyocytes (hESC-CMs)

Prolonging ß cell proliferation with a 3D culture system
Disque Platform technology for evaluating drug candidates to treat ß cell loss in patients with diabetes.

The modulatory effects of A2AR on NMDAR functionality using primary neurons and microglia cultures for potential neuroprotection in Alzheimer’s disease
Neurodegenerative Diseases Therapies; CNS Research, A2AR, Alzheimer's Disease, NMDAR, Acetylcholinesterase inhibitors

The impact of pan-KRAS inhibitors on cancer drug discovery
Read how Boehringer Ingelheim generated compounds to target the "undruggable" KRAS pathway with the help of Revvity's preclinical services.

SVEP1 as a regulator of GPCR-mediated vasoconstriction
This literature review describes how scientists uncovered multifunctional roles of SVEP1, a known contributor to cardiovascular disease.

Evaluating a novel nanoparticle platform for controlled liraglutide release in a Type II diabetes mouse model
Optical imaging using the IVIS® Platform to evaluate a novel nanoparticle system for controlled liraglutide release in a diabetic mouse model.


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