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Whitepaper
Relevance of multiparametric screening to drug discovery efforts
This white paper explores the importance of multiparametric screening to drug discovery efforts
Application Note
Machine-learning prediction of drug mechanism of action from high-content cell painting images
This application note demonstrates how machine-learning and high-content imaging can be applied to predict drug mechanism of actions.
Brochure
IVIS Spectrum 2 platform - illumination in focus
Discover the next generation in preclinical optical imaging, the IVIS Spectrum 2 and IVIS SpectruCT 2 systems.
Case Study
Assessment of MYC-driven progression of small cell lung cancer
Researchers at Huntsman Cancer Center use GEMM and the Quantum microCT system for evaluating small cell lung cancer.
Literature - Publication Review
Biopolymers Codelivering Engineered T Cells and STING Agonists can Eliminate Heterogenous Tumors
Using the IVIS® Spectrum non-invasive preclinical optical system to quantify tumor-specific T cells responses in NFAT-luciferase transgenic mice.
Case Study
Optical and microCT imaging enables noninvasive monitoring of EBV-induced neuroinvasion
Researchers use optical and microCT imaging to noninvasively monitor EBV-induced neuroinvasion in a mouse model.
Literature - Publication Review
DNA origami elevates the design of multispecific antibodies as cancer therapeutic agents
Publication review highlighting the use of the IVIS™ Lumina X5 optical imaging system and BioLegend Antibodies describe programmable T cell engagers (PTEs), a novel class of agents created with DNA origami, a nanotechnology that allows the precise spatial arrangement of biomolecules. When combined with antibodies, this approach holds great promise to develop specific and effective biomedical nanotherapies for diseases like cancer.
Whitepaper
Conditional knockout generation using targeted exon excision and synthetic introns
This white paper explores approaches for conditional knockout generation using targeted exon excision and synthetic introns.
Whitepaper
Establishing an automated high-throughput assay that supports the growth of prostate cancer organoids
Researchers concluded that their study demonstrates the ability to automate preclinical testing with prostate cancer organoids with diverse phenotypes.
Literature - Publication Review
SVEP1 as a regulator of GPCR-mediated vasoconstriction
This literature review describes how scientists uncovered multifunctional roles of SVEP1, a known contributor to cardiovascular disease.
Whitepaper
Generating a clonal HAP1LIG4(-) Cas9(+) cell line – an expert interview
An interview with Dr. Gerety, the Sanger Institute on generating a new HAP1 cell line and how it can help advance scientific discovery.
Application Note
Effectiveness of CRISPR-Cas9 using pools of Dharmacon™ Edit-R™ synthetic crRNAs in high-content analysis screening experiments
Find out about the effectiveness of CRISPR-Cas9 using pools of Dharmacon™ Edit-R™ synthetic crRNAs in HCA screening experiments.
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