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Application Note
Phenotype discrimination using the PhenoVue cell painting and multi-organelle staining kits
In this study, we analyzed the phenotypes induced by a set of 15 reference compounds using both the PhenoVue cell painting kit and the PhenoVue multi-organelle staining kit to compare phenotypic discrimination results of the two assays.
Technical Note
Expanding imaging multiplexing capabilities with PhenoVue Fluor 400LS - Phalloidin
This technical note offers tips and best practices relating to fluorescent signal quality using PhenoVue Fluor 400LS Phalloidin stain.
Application Note
Orthogonal validation of CRISPRCas9 and siRNA generated phenotypes using cell painting
Investigate cell cycle regulation through AURKB, GMNN, and PLK1 proteins. Learn how CRISPR-Cas9 and siRNA techniques, combined with high-content imaging on the Opera Phenix™ Plus, reveal their roles in cell division and genomic stability.
Infographic
Cell painting: from images to innovation
Learn everything you need to know about cell painting, including what it is, how it works, and what you need to get started.
Whitepaper
Cell painting - a cellular imaging and machine learning approach to drug discovery
Cell painting solutions from Revvity offer powerful phenotypic high-content screening methods that help to accelerate drug discovery by delivering more predictive data.
Application Note
Cell painting for phenotypic screening
Application note describing how to set-up a cell painting assay.
Application Note
Evaluation of drug selectivity and efficacy using PROTACs in a 3D co-culture spheroid model
The aim of this study was to evaluate the efficacy and selectivity of SJF1528, a pan-EGFR PROTAC, and MS39, a mutant-specific EGFR L858R PROTAC, while exploring the use of both high-content imaging and no-wash HTRF immunoassays in encapsulated 3D spheroid models.
Flyer
Cell line development solutions flyer
Optimize your biotherapeutic development with our CHOSOURCE™ platform for cell line development workflows
Whitepaper
Deconstructing and leveraging 3D structures of RNAs for novel therapeutics
A research team has engineered degradation-resistant mRNAs which could hold promise for treating various neurodegenerative disorders.
Guide
Guide to reducing the cost and time to set-up reproducible HTS/HCS with 3D cell models
Download our guide to reducing the costs and time required to set up reproducible high-throughput and high-content screens using 3D cell culture models.
Guide
How to transfer from animal-derived matrices to GrowDex - 3D cell culture matrix
Guide to transferring 3D cell culture to GrowDex hydrogel from animal-derived matrices.
Technical Note
Automated high-content assay using GrowDex-embedded spheroids dispensed on JANUS G3 automated liquid handling workstation
Improve throughput as well as assay statistics by automating the liquid handling steps of a 384-well, hydrogel-based high-content toxicity assay
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