Lead Optimization

Moving hits into high-quality lead series is the main goal of hit to lead optimization in drug discovery. During lead optimization, analogs of leads are prepared and synthesized to improve biological properties for clinical development. The aim is to improve target selectivity and biological activity, and reduce potential toxicity.

With our validated screening assays and multimode plate readers, state-of-the-art instruments for high content and in vivo imaging, integrated automation for liquid handling, and powerful analysis software, our portfolio brings consistent, accurate, physiologically relevant results for faster discoveries and impactful breakthroughs so you can gain more confidence in your discovery.

Revvity Lead Optimization solutions address challenging throughput variations by offering flexible and scalable options that adapt to the changing needs of the structure-activity relationship (SAR) assay development process and effectively handle standardized assays with specific well layouts and volumes.

Please read the brochure to discover the modular solutions from standalone instruments to fully integrated and configurable explorer™ G3 workstation.